Can Paxlovid cause a metallic taste in the mouth?
Yes. Paxlovid (nirmatrelvir/ritonavir) can cause taste changes, including a metallic or “metal in mouth” flavor. This side effect is commonly reported as part of taste disturbance or dysgeusia.
What does “metallic taste” feel like, and how long does it last?
People often describe it as a persistent metallic flavor during treatment. For many patients, it improves after the course is finished, but the exact timing varies from person to person.
Is metallic taste a known side effect of the components in Paxlovid?
Paxlovid contains ritonavir and nirmatrelvir. Taste changes are a recognized adverse effect reported with these medications (especially ritonavir), and Paxlovid can therefore carry that same risk.
What can you do if it happens?
Practical steps people use include:
- Taking Paxlovid with a small amount of food (if your clinician has said you can), which may reduce taste impact.
- Using sugar-free gum or lozenges if they don’t interfere with your medication plan.
- Staying hydrated and practicing good oral hygiene.
If the taste change becomes severe or affects eating and hydration, contact the prescriber.
When should you seek medical help?
Get medical advice promptly if you also have signs of a more serious reaction (such as swelling, rash, trouble breathing) or if you cannot keep enough fluids/food down. Also reach out if the metallic taste persists well beyond the treatment course.
Important: Paxlovid can interact with many medications
If you’re asking because you started Paxlovid and noticed a new symptom, it’s also worth confirming you’re not on a medication with a known interaction. Ritonavir can raise levels of some drugs, which can increase side effects. If you tell me what other medications you’re taking, I can help flag common interaction categories to discuss with your pharmacist or prescriber.