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Can Lipitor cause liver problems? Lipitor (atorvastatin) can raise liver enzymes in some people, though serious liver injury remains uncommon. Clinical studies show elevated ALT and AST levels in 0.7% to 3% of patients taking the drug. What do clinical trials show about liver enzymes? Trials tracked liver function tests at baseline and 12 weeks. Most enzyme elevations stayed mild and resolved when treatment stopped. Serious liver damage occurred in less than 0.1% of cases. Does Lipitor still need liver-function monitoring? Current guidelines recommend checking liver enzymes before treatment starts. Follow-up tests are no longer required for patients who show normal results at baseline. What happens if liver tests come back high? Doctors usually reduce the dose or stop Lipitor if ALT or AST rises above three times the upper limit of normal. Most patients recover quickly after stopping the drug. How does Lipitor compare with other statins? All statins carry some risk of liver enzyme elevation. Lipitor shows rates similar to other drugs in its class, including simvastatin and rosuvastatin.
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