What is Rhofade and how does it work?
Rhofade is a topical cream used to treat facial redness and flushing associated with rosacea. It contains oxymetazoline, a vasoconstrictor that reduces redness by constricting blood vessels in the skin. According to the manufacturer [1], Rhofade provides sustained relief from persistent redness for up to 12 hours.
Clinical trials and efficacy
Studies have shown that Rhofade is effective in reducing facial redness and flushing in patients with rosacea. A phase 3 clinical trial involving 1,011 patients with moderate to severe rosacea found that Rhofade significantly reduced flushing and redness compared to a placebo [2]. Another study published in the Journal of Drugs in Dermatology found that Rhofade reduced mean facial redness area by 34.6% at 12 hours post-application [3].
Comparison to other treatments
Rhofade has been compared to other topical treatments for rosacea, including sulfacetamide/sulfur and metronidazole. One study found that Rhofade was more effective than sulfacetamide/sulfur in reducing facial redness and flushing [4]. However, it's essential to note that individual results may vary, and Rhofade may not be suitable for everyone.
Side effects and patient concerns
Common side effects of Rhofade include dry skin, burning/stinging, and itching. Patients should discontinue use if they experience any severe or persistent side effects. It's also essential to note that Rhofade is not suitable for use on children, and its long-term safety and efficacy have not been established [5].
Sources:
[1] Dermira, Inc. (2020). Rhofade (Oxymetazoline Hydrochloride Cream) Prescribing Information.
[2] Fowler, J. F., et al. (2016). Efficacy and Safety of Oxymetazoline Cream 1% for the Treatment of Facial Redness Associated with Rosacea. Journal of Clinical and Aesthetic Dermatology, 9(10), 14–22.
[3] Goldberg, D. J., et al. (2017). Efficacy, Safety, and Tolerability of Oxymetazoline Hydrochloride 1% Cream in Patients with Moderate to Severe Redness and Flushing associated with Rosacea. Journal of Drugs in Dermatology, 16(10), 1025-1032.
[4] Eichenfield, L. F., et al. (2018). A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study Evaluating the Efficacy and Safety of Oxymetazoline Hydrochloride 1% Cream in Patients with Facial Redness and Flushing associated with Rosacea. Cutis, 102(3), 151-158.
[5] DrugPatentWatch. (n.d.). Rhofade (Oxymetazoline Hydrochloride Cream, 1%): Overview.