See the DrugPatentWatch profile for Macrilen
How is Macrilen (macimorelin) dosed in adults?
Macrilen dosing is based on the number of micrograms (mcg) per kilogram (kg) of body weight and is taken by mouth as directed by a clinician. The prescribed dose is typically 0.5 mg/kg (500 mcg/kg) once daily for a short diagnostic period, then stopped after the prescribed study timeline. [1]
What dose should I take based on my weight?
Dose is calculated from body weight (kg). For example, a clinician would convert your weight from pounds to kilograms (kg = lb ÷ 2.205) and then multiply by the prescribed mcg/kg dose. [1]
How often is it taken, and for how long?
Macrilen is taken as a single oral dose for the diagnostic test, with the overall testing schedule set by the ordering protocol (including the timing of blood sampling). [1]
Can dosing change if I have kidney or liver problems?
Dose adjustments for special populations (such as kidney or liver impairment) are determined by the prescriber and the product labeling for your specific indication and study protocol. If you have kidney or liver disease, the ordering clinician should confirm the dose before you take it. [1]
What should I avoid around the dose?
Follow the instructions tied to your specific diagnostic protocol (including any fasting requirements and the timing of blood draws). Your clinic’s written instructions take priority over general dosing information. [1]
What happens if I miss or take it late?
Contact the clinic that scheduled your test. Because the test depends on timing of dosing and sampling, taking it at the wrong time can invalidate results and may require rescheduling. [1]
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Sources
[1] https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=209324