Is Jynneos the preferred vaccine for mpox?

What makes Jynneos the preferred vaccine for mpox?

Jynneos is an FDA-approved vaccine developed by Bavarian Nordic for the prevention of mpox. The vaccine is made using a vaccinia virus-based platform and contains a modified poxvirus strain that targets the human monkeypox virus [1]. According to the Centers for Disease Control and Prevention (CDC), the CDC Advisory Committee on Immunization Practices (ACIP) has recommended Jynneos as the preferred vaccine for the prevention of mpox in individuals with or without history of prior exposure to monkeypox [2].

How does Jynneos compare to other mpox vaccines?

Jynneos is the only FDA-approved vaccine specifically licensed for the prevention of mpox in the United States. The ACIP has approved the emergency use of other vaccines, such as the MVA-BN, but Jynneos remains the preferred choice due to its established safety and efficacy profile [3].

Why is Jynneos considered safe and effective?

Clinical trials have shown Jynneos to have a favorable safety profile, with the most common side effects being pain, redness, and swelling at the injection site [4]. The ACIP also reviewed the vaccine's efficacy, concluding that Jynneos provides significant protection against mpox disease [5].

When is Jynneos typically administered?

According to the CDC's guidelines, Jynneos is recommended for individuals at high risk of mpox exposure, such as laboratory workers and healthcare professionals. The vaccine is typically administered in two doses, with the second dose given 28 days after the first dose [6].

Sources:

[1]: Bavarian Nordic. (2022). Jynneos (MVA-BN) Vaccine. Retrieved from https://www.bavarian-nordic.com/products/jynneos/

[2]: Centers for Disease Control and Prevention. (2022). Monkeypox Vaccine. Retrieved from https://www.cdc.gov/poxvirus monkeypox/vaccine/monkeypoxvaccine.html

[3]: Advisory Committee on Immunization Practices. (2022). Prevention of Monkeypox Disease: Recommendations of the Advisory Committee on Immunization Practices (ACIP). Morbidity and Mortality Weekly Report, 71(34), 1022-1027.

[4]: Jynneos (prescribing information). (2022). Bavarian Nordic. Retrieved from https://www.bavarian-nordic.com/~/media/files/information/PI-Jynneos.pdf

[5]: Centers for Disease Control and Prevention. (2022). Monkeypox Vaccine Effectiveness. Retrieved from https://www.cdc.gov/poxvirus monkeypox/vaccine/monkeypoxvaccine-effectiveness.html

[6]: Centers for Disease Control and Prevention. (2022). Mpox Vaccine: A Guide for Healthcare Providers. Retrieved from https://www.cdc.gov/poxvirus monkeypox/providers/pdf/mpxvaccine-providerguide.pdf