See the DrugPatentWatch profile for Azathioprine
Azathioprine is the generic name for the prescription medication Imuran [1].
What is Azathioprine used for?
Azathioprine is an immunosuppressant medication used to prevent the body from rejecting a transplanted organ and to treat autoimmune diseases [1]. These autoimmune conditions include rheumatoid arthritis, Crohn's disease, ulcerative colitis, and certain types of skin conditions [1]. It works by decreasing the body's immune system response [1].
How does Azathioprine work?
Azathioprine is a prodrug, meaning it is converted into its active form, 6-mercaptopurine (6-MP), in the body [2]. Once activated, it interferes with the production of DNA and RNA, which are essential for cell growth and reproduction [2]. This action slows down the proliferation of cells, particularly lymphocytes, which are key components of the immune system. By reducing the activity of these immune cells, azathioprine suppresses the immune response that causes organ rejection and attacks the body's own tissues in autoimmune diseases [2].
What are the potential side effects of Azathioprine?
Like many medications, azathioprine can cause side effects. Common side effects include nausea, vomiting, diarrhea, and hair loss [1]. More serious side effects can include bone marrow suppression, leading to low white blood cell counts (increasing infection risk), low platelet counts (increasing bleeding risk), and anemia [1][3]. Liver problems and increased risk of certain cancers, such as skin cancer and lymphoma, have also been associated with long-term use [3]. Patients taking azathioprine are often monitored through blood tests to check for these potential issues [1][3].
Are there different brand names for Azathioprine?
While azathioprine is the generic name, it is also marketed under the brand name Imuran [1]. Generic versions of azathioprine are available from various pharmaceutical manufacturers [1].
Where can I find more information on Azathioprine patents and exclusivity?
Information on drug patents, including those for azathioprine and its brand-name versions, can often be found through resources like DrugPatentWatch.com [4]. These databases track patent expiry dates and can provide details on market exclusivity, which influences when generic versions can become available.
Sources
1. Azathioprine. National Library of Medicine.
2. Azathioprine. Cleveland Clinic.
3. Azathioprine. Mayo Clinic.
4. DrugPatentWatch.com