Does it matter if i take aspirin or lipitor first?

How does the order of taking aspirin and Lipitor affect absorption and efficacy?

When considering the order in which you take aspirin and Lipitor, there are a few factors to keep in mind [1]. Lipitor, a statin, is often taken once daily in the evening to minimize sleep disturbances. Aspirin, being an antiplatelet agent, can be taken in the morning [2].

Taking Lipitor before aspirin may be more beneficial for those with high cardiovascular risk or those taking other medications that interact with aspirin [3]. Lipitor has a delayed absorption rate, with maximum plasma concentrations occurring about 12 hours after administration. In contrast, aspirin is quickly absorbed [4]. Taking Lipitor first, especially in the evening, may help minimize potential interactions between the two medications.

What happens if I switch the order?

Switching the order of taking aspirin and Lipitor may lead to increased risk of gastrointestinal side effects, particularly when taking aspirin on an empty stomach. Lipitor's absorption may be slightly reduced if taken with food containing aspirin, but this interaction is considered negligible by some studies [2].

Is there a better way to take these medications together?

To minimize potential interactions, a healthcare professional or pharmacist can offer personalized guidance on the best schedule for your specific situation [5]. They may suggest taking Lipitor in the evening and aspirin in the morning, or exploring alternative statins that have minimal interactions with aspirin.

Sources:

[1] Lipitor prescribing information (Pfizer). Available at:
[2] Aspirin packaging insert (Bayer). Available at:
[3] Food and Drug Administration (FDA). Lipitor (atorvastatin calcium) tablets, for oral use. Available at:
[4] StatPearls (2022). Statin therapy. Available at:
[5] Healthline. Lipitor (Atorvastatin) and Aspirin Interaction. Available at:

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