What is clindamycin?

Clindamycin is an antibiotic in the lincosamide class. It works by binding to the bacterial 50S ribosomal subunit and stopping bacteria from making proteins, which helps stop the infection.

Key points:
- Spectrum: Most effective against anaerobic bacteria and some Gram-positive cocci (like certain Staphylococcus and Streptococcus species). Not active against many Gram-negative bacteria.
- Forms and uses: Available as oral capsules, IV/IM injection, and topical forms (gel/cream for the skin, vaginal cream). Used for various infections such as skin and soft-tissue infections, respiratory and intra-abdominal infections, gynecologic infections, dental infections, and acne (topical) in some cases.
- Safety: Can cause stomach upset, diarrhea, and rash. A serious risk is Clostridioides difficile (C. diff) infection, which can occur with or without warning symptoms. Tell a clinician if you have a history of inflammatory bowel disease or severe diarrhea. Also caution in pregnancy and breastfeeding; it’s generally considered acceptable when clearly needed, but discuss with your provider.
- Considerations: Some bacteria can have inducible resistance to clindamycin, so doctors may test for this if resistance is a concern. Do not use if you’re allergic to clindamycin or lincomycin, and finish the full prescribed course even if you feel better.

If you’d like, tell me the specific infection you’re curious about (e.g., acne, dental infection, skin infection), and I can give you typical dosing ranges and safety notes for that use.