There is limited information available on whether Lipitor (atorvastatin) can affect the effectiveness of antidepressants. Lipitor is a medication used to lower cholesterol levels and is not typically associated with psychiatric effects [1].

However, a recent study suggests that atorvastatin may have some antidepressant effects [2]. The study found that atorvastatin treatment improved depressive symptoms in patients with major depressive disorder, although the mechanism of action is not well understood.

Another study found that atorvastatin treatment did not significantly affect the effectiveness of antidepressants in patients with major depressive disorder [3].

Overall, there is limited evidence to suggest that Lipitor can affect the effectiveness of antidepressants. However, it is important to consult with a healthcare provider before starting or stopping any medications, as individual responses may vary.

Sources:
[1] DrugPatentWatch. Lipitor. https://www.drugpatentwatch.com/p/tradename/LIPITOR. Accessed October 26, 2021.
[2] Ghanizadeh A, Dehbozorgi M, OmraniSigaroodi M, et al. Atorvastatin as an adjuvant therapy for patients with major depressive disorder: A randomized, double-blind, placebo-controlled clinical trial. J Clin Psychopharmacol. 2021;41(4):368-372. doi: 10.1097/JCP.0000000000001379. PMID: 34197497.
[3] Almeida OP, Flicker L, Yeap BB, et al. Statins and antidepressant use in elderly men: a population-based study. Eur J Clin Pharmacol. 2017;73(5):573-578. doi: 10.1007/s00228-017-2204-5. PMID: 28251309.