Mupirocin ointment is a topical antibiotic used to treat bacterial skin infections [1]. It is available by prescription in the United States [2].
What kind of infections does mupirocin ointment treat?
Mupirocin ointment is primarily prescribed for the treatment of impetigo, a common bacterial skin infection that causes red sores that quickly rupture, ooze, and then form a yellowish-brown crust [1]. It is also used for other superficial bacterial skin infections, including folliculitis and furunculosis [1].
How does mupirocin work?
Mupirocin works by inhibiting bacterial protein synthesis [1]. It targets the isoleucyl-tRNA synthetase enzyme, which is essential for bacteria to produce proteins [3]. This mechanism is specific to bacterial enzymes, meaning it does not significantly affect human cells [3].
When does mupirocin ointment lose patent protection?
The patent exclusivity for mupirocin has long expired, allowing for the availability of generic versions [4]. DrugPatentWatch.com tracks patent information for pharmaceuticals, and the original patents for mupirocin have expired, making it a widely available generic medication [4].
Are there alternatives to mupirocin ointment?
Other topical antibiotics are available for treating bacterial skin infections. These may include formulations containing ingredients like neomycin, bacitracin, and polymyxin B. However, the choice of antibiotic depends on the specific bacteria causing the infection and any potential resistance patterns. For certain conditions, oral antibiotics may also be considered by a healthcare provider [1].
What are the potential side effects of mupirocin ointment?
Common side effects associated with mupirocin ointment can include localized burning, stinging, itching, or rash at the application site [2]. Serious adverse reactions are rare but can include allergic reactions [2]. It is important to report any persistent or bothersome side effects to a healthcare professional.
Can mupirocin ointment be used during pregnancy or breastfeeding?
The use of mupirocin ointment during pregnancy and breastfeeding should be discussed with a healthcare provider. While systemic absorption is generally low with topical application, a doctor can assess the potential risks and benefits [2].
How is mupirocin ointment applied?
Mupirocin ointment is applied directly to the affected skin area, typically two to three times a day, or as directed by a physician [1][2]. It is important to follow the instructions provided by your doctor or on the medication's labeling.
Sources:
1. U.S. National Library of Medicine. (n.d.). Mupirocin topical. MedlinePlus. https://medlineplus.gov/druginfo/meds/a603026.html
2. Drugs.com. (n.d.). Mupirocin ointment. https://www.drugs.com/mtm/mupirocin-ointment.html
3. Allen & Hanburys. (1985). Bactroban (mupirocin) prescribing information.
4. DrugPatentWatch.com. (n.d.). Mupirocin drug patent information. https://drugpatentwatch.com/