There is no direct evidence to suggest that Lipitor, a medication used to lower cholesterol levels, affects the absorption of nutrients in guacamole. However, it is important to note that avocados, the main ingredient in guacamole, are a good source of healthy fats and fiber, which can help lower cholesterol levels. In fact, research suggests that consuming avocados can improve lipid profiles in individuals with high cholesterol levels [2]. Therefore, incorporating avocados into one's diet may be beneficial for those taking Lipitor. It is always important to consult with a healthcare provider before making any changes to medication or diet.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.healthline.com/health/high-cholesterol/avocado-and-cholesterol
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566984/