Prolia side effects?

What are the common side effects of Prolia?

Prolia is a medication used to treat osteoporosis in postmenopausal women and skeletal-related events in patients with bone metastases from solid tumors.

According to the manufacturer, Amgen [1], the most common side effects of Prolia include:

* Injection site reactions, such as pain, swelling, or redness at the site of injection
* Back pain
* Fatigue
* Dizziness
* Nausea
* Constipation

How common are these side effects?

The incidence of these side effects varies in Prolia clinical trials. For example, injection site reactions occurred in 12.6% of patients who received Prolia in a pivotal study [1]. Back pain occurred in 17.4% of patients in this same study.

What about rare but serious side effects?

Rare but serious side effects of Prolia include:

* Decreased bone density in the hip and spine
* Atypical femoral fractures
* Osteonecrosis of the jaw
* Increased risk of infections (e.g., pneumonia, bronchitis)

Who should not take Prolia?

People with certain medical conditions, such as a history of osteonecrosis of the jaw or a history of atypical femoral fractures, should not take Prolia.

What should healthcare professionals consider when prescribing Prolia?

Healthcare professionals should be aware of the potential risk of rare side effects when prescribing Prolia, especially in patients with pre-existing conditions. Regular monitoring of patients taking Prolia is recommended.

Sources:

[1] Amgen. Prolia prescribing information. Retrieved from https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/125320s031lbl.pdf

Sources:

1. Amgen. Prolia prescribing information.