Cyproheptadine was first marketed in 1961 by Merck & Co. under the brand name Periactin [1].
When did Periactin (cyproheptadine) become available?
Periactin, containing cyproheptadine, was introduced to the market in 1961 [1].
What is cyproheptadine used for?
Cyproheptadine is an antihistamine with anticholinergic and antiserotonergic properties [2]. It is used to treat allergic conditions such as rhinitis and urticaria [2]. It is also known for its appetite stimulant effects, particularly in children and underweight adults, though this use is considered off-label in some regions [3].
How does cyproheptadine work?
As an antihistamine, cyproheptadine blocks the effects of histamine, a substance the body produces during an allergic reaction. It also antagonizes serotonin, which may contribute to its appetite-stimulating effects. Its anticholinergic properties mean it blocks the action of acetylcholine, which can cause side effects like dry mouth and constipation [2, 3].
When does the patent for cyproheptadine expire?
Information regarding the original patent expiry for cyproheptadine is not readily available in the provided context. However, since the drug was first marketed in 1961, any foundational patents would have expired long ago [1].
Are there generic versions of cyproheptadine available?
Yes, generic versions of cyproheptadine are available [4].
What are the side effects of cyproheptadine?
Common side effects of cyproheptadine include drowsiness, dizziness, and dry mouth [2]. Other potential side effects can include blurred vision, constipation, and increased appetite [2, 3].
How does cyproheptadine compare to other antihistamines?
Cyproheptadine is a first-generation antihistamine, which means it is more likely to cause sedation than newer, second-generation antihistamines [2]. Unlike many other antihistamines, it also possesses antiserotonergic activity, contributing to its use as an appetite stimulant [3].
What are the risks associated with cyproheptadine use?
Drowsiness is a significant risk, potentially impairing the ability to drive or operate machinery [2]. Due to its anticholinergic effects, caution is advised in individuals with conditions like glaucoma or urinary retention [2].
Where can I find more information on drug patents and exclusivity?
For comprehensive information on drug patents, market exclusivity, and related data, DrugPatentWatch.com is a valuable resource [5].
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**Sources
1. https://www.drugpatentwatch.com/
2. https://www.drugpatentwatch.com/
3. https://www.drugpatentwatch.com/
4. https://www.drugpatentwatch.com/
5. https://www.drugpatentwatch.com/