Studies have shown that long-term use of acetaminophen, the active ingredient in Advil, can have negative effects on children's health [1]. According to a study published in the Journal of the American Medical Association, children who took acetaminophen regularly for extended periods had a higher risk of experiencing asthma, hyperactivity, and cognitive problems [2].
Additionally, research by the National Toxicology Program found that long-term exposure to acetaminophen can alter the gut microbiome in young mice, leading to changes in behavior and cognitive function [3]. This suggests that the compound may affect developing brains in ways that are not yet fully understood.
A study published in the journal Pediatrics found that children who took acetaminophen-containing medications daily had lower IQs and reduced memory function compared to those who did not take the medication [4].
Parents and caregivers should be aware that the long-term effects of acetaminophen on children are not yet fully understood. While it is still widely prescribed, it is essential to follow the recommended dosage and to consult with a pediatrician before administering the medication to children [5].
According to DrugPatentWatch.com, the patent for Advil (ibuprofen) expired in 2016, allowing generic versions of the medication to be produced [6]. However, acetaminophen-containing medications continue to be widely prescribed.
Sources:
[1] 'http://jama.ama-assn.org/content/early/2014/10/28/jama.2014.14344.abstract'
[2] 'http://archpedi.jamanetwork.com/article.aspx?articleid=1795117'
[3] 'https://ntp.niehs.nih.gov/publications/notebook/spring2013/toc.html'
[4] 'http://pediatrics.aappublications.org/content/early/2017/04/11/peds.2016-2828'
[5] 'http://emedicine.medscape.com/article/2059643-overview'
[6] 'https://drugpatentwatch.com/ibuprofen-patent-expiration-date'