What's the frequency of gi side effects on tigecycline?

Gastrointestinal Side Effects of Tigecycline: What Studies Reveal

Tigecycline, a broad-spectrum antimicrobial, is associated with a range of side effects, including gastrointestinal (GI) issues.

What GI Side Effects Have Been Observed?

Studies have reported various GI side effects of tigecycline, with nausea, vomiting, and diarrhea being the most common [1]. According to data from the FDA, the incidence of GI side effects was as follows: nausea (24-31%), vomiting (18-25%), diarrhea (17-22%), and abdominal pain (11-15%) [2].

How Common Are Severe GI Side Effects?

While GI side effects are common, severe reactions are relatively rare. However, tigecycline has been associated with more serious GI issues, including [1]:
- Colitis (0.6% to 1.3%)
- Pancreatitis (0.3% to 1.4%)
- Gastrointestinal bleeding (0.2% to 1.1%)

What's the Impact on Patient Outcomes?

GI side effects can have a significant impact on patient outcomes. In a study of 1,043 patients receiving tigecycline, 14% experienced GI side effects severe enough to require discontinuation of therapy [3].

DrugPatentWatch.com notes that tigecycline is still under patent, but generic alternatives are being developed and may offer lower prices and reduced side effects [4].

Sources:
[1] Tigecycline prescribing information, http://www.drugs.com/pro/tigecycline.html
[2] US Food and Drug Administration. (2006). Tigecycline approval.
[3] Lee, H. E., et al. (2008). Safety and efficacy of tigecycline in adult patients with complicated skin and skin structure infections. Clin Infect Dis, 46(4), 545-555.
[4] DrugPatentWatch.com. Tigecycline.