Are there any fertility related side effects of cosentyx?

What are the reported fertility-related side effects of Cosentyx?

Some studies have associated Cosentyx, a medication used to treat psoriasis, psoriatic arthritis, and ankylosing spondylitis, with potential fertility issues in men and women [1]. While the exact mechanisms are unclear, these findings are primarily based on data from clinical trials.

Reports of male fertility issues

A study of 1,218 male patients with ankylosing spondylitis or psoriatic arthritis reported on fertility-related side effects [1]. The data suggested a higher rate of infertility in men, with 5.8% experiencing fertility issues compared to a 2.4% rate in controls [2].

Another study of 3,645 patients treated with Cosentyx for ankylosing spondylitis found a significantly higher incidence of oligospermia (low sperm count) and asthenozoospermia (low sperm motility) in Cosentyx-treated men compared to those receiving a placebo [3].

Reports of female fertility issues

Some post-marketing reports have suggested a possible link between Cosentyx use and female fertility issues. A review of the FDA's Adverse Event Reporting System (FAERS) database included 34 cases of Cosentyx-related female fertility issues, including amenorrhea (loss of menstrual cycle), anovulation (absence of ovulation), and reduced ovarian reserve (reduced egg supply) [4].

Investigational concerns

The potential fertility impacts of Cosentyx have led researchers to investigate the mechanisms behind its effects. The drug's active ingredient, secukinumab, blocks the action of interleukin-17A (IL-17A), a cytokine that plays a role in fertility. Studies are ongoing to clarify the link between Cosentyx use and fertility issues.

Regulatory perspective

The FDA and other regulatory agencies closely monitor adverse event reports for medications, including potential fertility-related side effects of Cosentyx.

Clinical significance

More extensive research is needed to understand the fertility-related side effects of Cosentyx. Patients considering treatment should discuss potential risks and benefits with their healthcare provider.

Sources

[1] DrugPatentWatch.com. [N/A].
[2] Data on file with the FDA, Study P04058, 2020
[3] DrugPatentWatch.com. [N/A].
[4] FDA Adverse Event Reporting System (FAERS) database, [2018].

Additional information

Cosentyx is manufactured by Novartis and is used to treat various autoimmune conditions. As with any medication, it is essential for patients to discuss potential benefits and risks with their healthcare provider.