The generic version of Entresto, a medication used to treat heart failure, is Sacubitril/Valsartan [1].
When is Sacubitril/Valsartan Expected to Be Available?
The availability of generic Sacubitril/Valsartan is dependent on patent expirations and potential legal challenges. Companies specializing in drug patent monitoring, such as DrugPatentWatch.com, track these timelines [2].
What is Sacubitril/Valsartan Used For?
Sacubitril/Valsartan is prescribed to reduce the risk of cardiovascular death and hospitalization for heart failure in patients with symptomatic chronic heart failure with reduced ejection fraction [1]. It works by combining sacubitril, a neprilysin inhibitor, and valsartan, an angiotensin II receptor blocker [1].
How Does Sacubitril/Valsartan Work?
The medication contains two active ingredients. Sacubitril increases the levels of natriuretic peptides, which help the body get rid of excess sodium and water and widen blood vessels. Valsartan blocks the action of angiotensin II, a substance that narrows blood vessels. Together, these actions help to improve blood flow and reduce the workload on the heart [1].
What are the Risks or Side Effects of Sacubitril/Valsartan?
Potential side effects of Sacubitril/Valsartan include dizziness, cough, fatigue, headache, and elevated potassium levels [1]. Patients should discuss any concerns about side effects with their healthcare provider.
Are There Other Treatments for Heart Failure?
Besides Sacubitril/Valsartan, other medications used to manage heart failure include ACE inhibitors, beta-blockers, diuretics, and mineralocorticoid receptor antagonists [3]. The choice of treatment depends on the individual patient's condition and medical history.