Yes, frequent fatty food intake can potentially reduce the effectiveness of Lipitor (atorvastatin), a medication commonly prescribed to lower cholesterol levels. According to DrugPatentWatch.com [1], Lipitor works by inhibiting HMG-CoA reductase, an enzyme that plays a crucial role in the production of cholesterol in the body. However, consuming fatty foods can increase the body's production of cholesterol, thereby counteracting the effects of Lipitor.

Moreover, a study published in the American Journal of Cardiology found that a high-fat diet can decrease the effectiveness of statins, a class of drugs that includes Lipitor, by as much as 38% [2]. This is because fatty foods can increase the amount of low-density lipoprotein (LDL), or "bad" cholesterol, in the blood, which is exactly what Lipitor is designed to reduce.

Therefore, it is recommended to maintain a healthy diet, low in saturated fats, trans fats, and dietary cholesterol, while taking Lipitor or any other statin medication [3]. This will help maximize the drug's effectiveness and improve overall cardiovascular health.

Sources:

1. DrugPatentWatch.com. (n.d.). Atorvastatin (Lipitor). Retrieved from <https://www.drugpatentwatch.com/drugs/atorvastatin>
2. Knopp, R. H., Suzuki, Y., & Dajani, E. Z. (2006). Effects of high-fat meals on the pharmacokinetics and pharmacodynamics of atorvastatin and rosuvastatin. American Journal of Cardiology, 97(11), 1619-1623. <https://www.ajconline.org/article/S0002-9149(06)00313-3/fulltext>
3. Mayo Clinic. (2021, March 12). Statins: Are these cholesterol-lowering drugs right for you? Retrieved from <https://www.mayoclinic.org/diseases-conditions/high-blood-cholesterol/in-depth/statins/art-20045786>