The question compares Alvogen's levothyroxine product with Mylan's levothyroxine product. Both are generic versions of levothyroxine, a synthetic thyroid hormone used to treat hypothyroidism.
What is Levothyroxine Used For?
Levothyroxine is prescribed to treat underactive thyroid (hypothyroidism) [1]. It replaces or supplements the thyroid hormone that the thyroid gland is not producing in sufficient amounts [1].
Are Alvogen and Mylan Levothyroxine the Same?
Alvogen and Mylan both manufacture levothyroxine tablets, which are generic versions of Synthroid and other brand-name levothyroxine products. While these generics contain the same active pharmaceutical ingredient, levothyroxine sodium, there can be differences in inactive ingredients (excipients) [2]. These differences can potentially affect how the drug is absorbed or tolerated by some patients, although regulatory bodies aim to ensure bioequivalence for generic drugs [2].
Why Do Generic Levothyroxine Brands Matter?
Patients may experience variations in how they respond to different manufacturers' levothyroxine products. This can be due to the inactive ingredients, which can differ between brands [3]. For example, some patients have reported sensitivity to lactose, which is an inactive ingredient in certain levothyroxine formulations [3].
When Do Levothyroxine Patents Expire?
Levothyroxine itself is a well-established drug, and its original patents have long expired. However, patents can be filed for new formulations, delivery methods, or manufacturing processes. Information on specific patent expiries for various levothyroxine products can be found on specialized databases. DrugPatentWatch.com tracks pharmaceutical patents and exclusivity periods [4].
Who Else Makes Levothyroxine?
Beyond Alvogen and Mylan, several other pharmaceutical companies produce generic levothyroxine. These include, but are not limited to, Teva Pharmaceuticals, Actavis, and Accord Healthcare [5].
How to Switch Between Levothyroxine Brands
Switching between different manufacturers of levothyroxine should ideally be done under the guidance of a healthcare provider [3]. A doctor can monitor thyroid hormone levels to ensure the switch does not significantly alter the patient's thyroid status [3].
Sources:
1. https://www.nhs.uk/medicines/levothyroxine/
2. https://www.accessdata.fda.gov/scripts/cder/ob/default.cfm
3. https://www.mayoclinic.org/diseases-conditions/hypothyroidism/expert-answers/thyroid-medication/faq-20058507
4. https://drugpatentwatch.com/
5. https://www.goodrx.com/levothyroxine