See the DrugPatentWatch profile for Losartan
Losartan is prescribed to treat high blood pressure and to help protect the kidneys in patients with type 2 diabetes who have high blood pressure [1]. It is also used to lower the risk of stroke in people with high blood pressure and an enlarged heart [1].
How Does Losartan Work?
Losartan belongs to a class of drugs called angiotensin II receptor blockers (ARBs) [2]. It works by blocking the action of angiotensin II, a substance in the body that narrows blood vessels and raises blood pressure [1]. By preventing this action, losartan causes blood vessels to relax and widen, which lowers blood pressure [1].
What Are the Potential Side Effects of Losartan?
Like all medications, losartan can cause side effects, though not everyone experiences them [3]. Common side effects include dizziness, fatigue, and upper respiratory tract infection [3]. Less common but potentially serious side effects can include changes in kidney function, especially in patients with pre-existing kidney disease or heart failure [3]. It can also cause hyperkalemia, an elevated level of potassium in the blood [3]. In rare cases, angioedema, a severe allergic reaction causing swelling of the face, lips, tongue, or throat, can occur [3].
When Might Losartan Patents Expire?
Patent expiration dates for pharmaceuticals can be complex and are subject to various factors, including patent term extensions and exclusivity periods. Information regarding specific patent expirations for losartan can be found through patent tracking resources [4].
Who Manufactures Losartan?
Losartan is available as a generic medication manufactured by numerous pharmaceutical companies [5]. The original branded product was developed by Merck & Co. [5].
How Does Losartan Compare to Other Blood Pressure Medications?
Losartan, as an ARB, offers an alternative mechanism of action compared to other classes of blood pressure medications like ACE inhibitors, calcium channel blockers, or diuretics [2]. While all aim to lower blood pressure, they do so through different pathways, and individual patient responses can vary [2]. Your doctor will consider your specific health conditions when choosing the most appropriate medication [2].
What Are the Risks of Not Taking Losartan If Prescribed?
If losartan is prescribed to manage high blood pressure, neglecting to take it as directed can lead to uncontrolled hypertension [1]. This can increase the risk of serious health problems such as stroke, heart attack, kidney failure, and vision loss [1]. For patients with type 2 diabetes and high blood pressure, uncontrolled blood pressure while not taking losartan can accelerate kidney damage [1].
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Sources:
[1] https://www.npr.org/sections/health-shots/2022/09/07/1121418888/losartan-blood-pressure-drug-shortage-fda-medication
[2] https://www.mayoclinic.org/drugs-supplements/losartan-oral-route/description/drg-20066978
[3] https://www.webmd.com/drugs/2/7663/losartan-oral/details
[4] https://drugpatentwatch.com/
[5] https://www.rxlist.com/losartan-drug.htm