Can Lyrica (pregabalin) cause low blood pressure?
Yes. Lyrica (pregabalin) can cause dizziness and somnolence, which can occur with or contribute to low blood pressure symptoms such as lightheadedness, especially when standing up (orthostatic hypotension). The prescribing information also includes warnings about dizziness and drowsiness, and these effects can be clinically associated with reduced blood pressure in some patients.
What symptoms would suggest low blood pressure from Lyrica?
Patients may notice lightheadedness, feeling faint, blurred vision, or dizziness when standing or after dose changes. Because these symptoms overlap with common Lyrica side effects (like dizziness), it’s important to check blood pressure if symptoms are new, worsening, or happening soon after starting the medication or increasing the dose.
Who is more at risk of Lyrica-related blood pressure problems?
The risk is higher when Lyrica is combined with other factors that lower blood pressure, such as:
- Other blood pressure–lowering medicines
- Dehydration or illness that reduces fluid intake
- Older age or underlying cardiovascular issues
- Starting treatment or increasing the dose, when dizziness is more likely
When should someone seek urgent care?
Seek urgent medical help if low blood pressure symptoms come with severe fainting, chest pain, shortness of breath, confusion, or injury from falling. For less severe symptoms, contacting a clinician promptly is appropriate to review doses and possible interactions.
What should patients do if they suspect Lyrica is lowering their blood pressure?
Do not stop Lyrica suddenly without medical advice. Instead:
- Measure blood pressure (including standing and sitting/lying, if feasible) and write down readings and timing.
- Tell the prescriber about dizziness/lightheadedness, other medications, and any recent dose changes.
- Ask whether dose adjustment or alternative therapy is needed.
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