Can Ozempic (semaglutide) cause gallbladder problems?
Yes. Ozempic can be associated with gallbladder (biliary) problems, including gallstones and inflammation of the gallbladder (cholecystitis). Drug safety information for GLP-1 medicines includes reports of these complications. [1]
What kinds of gallbladder problems have been reported?
Reported issues include:
- Gallstones (cholelithiasis) [1]
- Inflammation or infection of the gallbladder (cholecystitis) [1]
Who may be at higher risk?
Risk may be higher in people who develop rapid weight loss, because weight changes can increase the likelihood of gallstone formation. GLP-1 treatment can lead to weight loss, which may contribute to gallbladder risk. [1]
What symptoms should you watch for?
Seek urgent medical care if you develop signs consistent with gallbladder trouble, such as:
- Pain in the upper right side of the abdomen (or pain that spreads to the back/right shoulder)
- Fever
- Yellowing of the skin or eyes (jaundice)
- Persistent vomiting or severe abdominal pain [1]
What should you do if you get symptoms while taking Ozempic?
Stop and get medical advice promptly. A clinician may evaluate you for gallstones or cholecystitis (often with exam and imaging) and decide whether Ozempic should be paused or discontinued based on your diagnosis and severity. [1]
How to think about the benefit-risk tradeoff
Gallbladder problems are a known potential adverse effect, but many people use Ozempic without developing them. The key is to recognize symptoms early and discuss your individual risk factors (including prior gallstones, if any) with your prescriber. [1]
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Sources
[1] https://www.drugs.com/medical-answers/ozempic-gallbladder-problems-3577347/