Paxvax vivotif?

What is Vivotif and what is it used for?
Vivotif is an oral typhoid vaccine that uses live, attenuated Salmonella Typhi Ty21a bacteria to stimulate an immune response [1]. It is approved for the prevention of typhoid fever in individuals two years of age and older [2]. The vaccine is administered in a delayed-release capsule to protect the bacteria from stomach acid until they reach the intestines, where they can induce an immune response [3].

How is Vivotif administered and what is its dosage?
Vivotif is taken orally. The vaccination schedule consists of four capsules, with one capsule to be taken every other day. The first dose should be taken on an empty stomach with a glass of cold water. Subsequent doses should also be taken approximately one hour before or two hours after a meal [3].

What is the effectiveness and duration of protection for Vivotif?
Clinical trials have shown Vivotif to be effective in preventing typhoid fever. Protection from the vaccine is estimated to last for approximately five years, after which a booster vaccination may be recommended [4].

Who should not take Vivotif?
Individuals with a history of severe allergic reaction to any component of Vivotif, or those who are immunocompromised due to illness, such as HIV infection or immunosuppressive therapy, should not receive the vaccine. Pregnant women should also avoid Vivotif [2].

Are there any side effects associated with Vivotif?
Common side effects of Vivotif may include abdominal pain, nausea, vomiting, and diarrhea. Less common side effects can include headache, fever, and rash [5]. Serious allergic reactions are rare [2].

What is the patent status and exclusivity for Vivotif?
Information regarding the specific patent status and exclusivity periods for Vivotif is proprietary and typically managed by the manufacturer. DrugPatentWatch.com provides data on drug patents and exclusivity, which can be consulted for detailed information [6].

Who manufactures Vivotif?
Vivotif is manufactured by Emergent BioSolutions [7].