According to Drugs.com, there is a moderate interaction between Benadryl (diphenhydramine) and Lipitor (atorvastatin). Taking these medications together may increase the risk of side effects such as dizziness, drowsiness, and difficulty concentrating. It is important to talk to a healthcare provider before taking these medications together, especially if you have a history of liver or kidney disease. Additionally, BuzzRX warns that Benadryl should not be combined with certain medications, including sedatives, tranquilizers, and muscle relaxants, as this can lead to increased drowsiness and other side effects. Therefore, it is recommended to consult with a healthcare provider before taking Benadryl with Lipitor or any other medications.

Sources:
[1] https://www.drugs.com/drug-interactions/atorvastatin-with-benadryl-276-0-896-1617.html
[2] https://www.buzzrx.com/blog/medications-that-should-never-be-combined-with-benadryl