Based on the information available, there are no direct interactions between Advil (ibuprofen) and Doxycycline that have been reported. However, it is always recommended to consult with a healthcare professional or pharmacist before combining any medications, as individual sensitivities and potential interactions may vary.

Ibuprofen, the active ingredient in Advil, is a nonsteroidal anti-inflammatory drug (NSAID) commonly used for pain relief, fever reduction, and inflammation. Doxycycline is an antibiotic used to treat a variety of bacterial infections.

While there are no known interactions between these two medications, it is important to note that NSAIDs like ibuprofen can increase the risk of stomach ulcers and bleeding, especially when taken in high doses or for extended periods. Doxycycline can also cause stomach upset in some individuals. Therefore, taking these medications together may increase the risk of gastrointestinal side effects.

Additionally, both Advil and Doxycycline can affect kidney function. Concurrent use may increase the risk of kidney-related side effects, particularly in individuals with pre-existing kidney issues or those taking high doses of these medications.

In summary, while there are no direct interactions between Advil and Doxycycline, it is crucial to be aware of potential gastrointestinal and kidney-related side effects when taking these medications together. Always consult a healthcare professional or pharmacist for personalized advice.

Sources:

1. [Drugs.com](https://www.drugs.com/drug-interactions/doxycycline-ibuprofen-812-133-175.html)
2. [Mayo Clinic](https://www.mayoclinic.org/drugs-supplements/ibuprofen-oral-route/description/drg-20068891)
3. [Drugs.com](https://www.drugs.com/doxycycline.html)
4. [DrugPatentWatch.com](https://www.drugpatentwatch.com/drugs/doxycycline)