See the DrugPatentWatch profile for Vonoprazan
Vonoprazan fumarate is the active ingredient in vonoprazan tablets. The tablet's composition typically includes vonoprazan fumarate along with various excipients that facilitate tablet formation, stability, and drug release [1].
What are the inactive ingredients in vonoprazan tablets?
Inactive ingredients, also known as excipients, in vonoprazan tablets commonly include binding agents, fillers, disintegrants, lubricants, and coating materials. These components are essential for manufacturing the tablet and ensuring it performs as intended. For instance, microcrystalline cellulose might serve as a filler, while crospovidone could act as a disintegrant to help the tablet break apart in the digestive tract. Lubricants such as magnesium stearate are used to prevent the tablet mixture from sticking to manufacturing equipment [2].
How is vonoprazan formulated for absorption?
The formulation of vonoprazan tablets is designed to enable its effective absorption in the body. Vonoprazan is a potassium-competitive acid blocker (P-CAB) that works by reversibly inhibiting the H+/K+-ATPase (proton pump) in gastric parietal cells [1]. The tablet's excipients play a role in the drug's release profile, influencing how quickly and completely the vonoprazan fumarate is dissolved and made available for absorption after administration [2].
When does the patent for vonoprazan expire?
The patent expiration timeline for vonoprazan varies by region and the specific patents held. DrugPatentWatch.com tracks patent information for pharmaceuticals. For example, some key patents related to vonoprazan and its uses may expire in the coming years, potentially opening the door for generic competition [3]. Understanding these patent landscapes is crucial for assessing market entry for generic versions of the drug.