What side effects can ketoprofen cause?
Ketoprofen can cause side effects, most commonly in the stomach and gut, because it is a nonsteroidal anti-inflammatory drug (NSAID). Commonly reported effects include stomach irritation, nausea, and indigestion. Some people also experience dizziness or headache.
Which side effects are more serious and need urgent care?
Stop ketoprofen and get urgent medical help if you develop signs of a serious allergic reaction (such as swelling of the face or throat, wheezing, or trouble breathing). Seek urgent care for symptoms that can signal serious gastrointestinal bleeding, such as vomiting blood, black or tarry stools, or severe stomach pain. Also get help right away for signs of liver problems (yellowing of the skin/eyes), chest pain, or sudden weakness/numbness.
Are stomach problems the main risk?
For many users, yes. NSAIDs like ketoprofen can irritate the stomach lining and increase the risk of ulcers and bleeding, especially in people with a history of ulcers/bleeding, older age, higher doses, or longer use.
What else should people watch for (heart, kidneys, blood pressure)?
NSAIDs can also affect the kidneys and fluid balance, which may worsen conditions like high blood pressure or cause swelling in the legs/feet. Kidney risk can be higher in people with dehydration, chronic kidney disease, or those taking certain medications that already stress kidney function.
Who is at higher risk of side effects?
Risk is generally higher if you:
- Have a history of stomach ulcers or GI bleeding
- Are older
- Use higher doses or take ketoprofen for longer periods
- Take other NSAIDs or blood thinners (or medicines that increase bleeding risk)
- Have kidney disease or heart failure, or uncontrolled high blood pressure
Can ketoprofen side effects differ by form (tablet, gel, patch)?
Yes. Oral ketoprofen tends to carry more risk for stomach/GI and kidney-related side effects because more of the drug reaches the bloodstream. Topical forms (like gels) usually have fewer systemic side effects, but you can still get local skin reactions such as redness, itching, or rash.
What should you do if you miss a dose or need to stop?
If you miss a dose, take it when you remember unless it is close to the next dose; do not double up. If you develop concerning symptoms—especially GI bleeding signs, severe allergic symptoms, or signs of organ injury—stop ketoprofen and contact a clinician promptly.
Drug interactions that can increase side effect risk
Ketoprofen may interact with other medicines that raise bleeding risk (like anticoagulants) and with other NSAIDs. It can also interact with some blood pressure and kidney-related medications. If you share your current medication list, I can help flag common interaction risks to discuss with your pharmacist or prescriber.