Can ezetimibe cause constipation?
Yes. Constipation is listed as a possible side effect of ezetimibe (Zetia) in patient labeling and drug safety information. [1]
What does the evidence say about how common it is?
Constipation appears as an adverse reaction in ezetimibe’s documented side-effect profile, but it is generally not one of the most common effects compared with more typical gastrointestinal complaints. [1]
What to do if constipation happens while taking ezetimibe
If constipation develops after starting ezetimibe, it is reasonable to discuss it with a clinician—especially if it is severe, persistent, or comes with red-flag symptoms such as severe abdominal pain, vomiting, or blood in the stool. Your clinician may suggest supportive measures (dietary fiber, fluids, or an appropriate over-the-counter laxative) and check whether any other medicines or conditions could be contributing. [1]
Does constipation happen more with ezetimibe plus a statin?
Constipation can occur with ezetimibe when used alone or with other cholesterol-lowering drugs, because gastrointestinal side effects can overlap across therapies. The overall likelihood can vary by the specific regimen and the patient’s baseline risks for constipation. [1]
What else might cause constipation in people taking cholesterol medicines?
Many factors unrelated to ezetimibe can contribute, including opioids, iron supplements, dehydration, low-fiber diet, slowed gut motility, and underlying bowel conditions. A clinician can help determine whether ezetimibe is the likely trigger versus another cause. [1]
Source
- Drug information for ezetimibe (Zetia) including side effects (constipation). https://www.drugs.com/sfx/ezetimibe-side-effects.html