Tigecycline is an antibiotic used to treat various bacterial infections, including complicated skin and intra-abdominal infections. However, misuse of this medication can occur due to several patient factors.

One such factor is the patient's renal function. Tigecycline is primarily eliminated by the liver, but renal impairment can affect its clearance, leading to potential drug accumulation and increased risk of adverse effects [1]. Therefore, healthcare providers must adjust the dosage for patients with renal impairment to mitigate the risk of misuse.

Another factor is the patient's hepatic function. Since tigecycline is mainly metabolized in the liver, hepatic impairment can also affect its clearance and increase the risk of adverse effects [1]. Healthcare providers should consider the patient's hepatic function when prescribing tigecycline.

Additionally, the patient's age can be a factor in tigecycline misuse. Elderly patients are more susceptible to adverse effects due to decreased renal and hepatic function, which can affect tigecycline clearance [2]. Therefore, healthcare providers should exercise caution when prescribing tigecycline to elderly patients.

Lastly, the patient's weight can also be a factor. Tigecycline's clearance is affected by body weight, and obese patients may require higher doses to achieve therapeutic concentrations [3]. Healthcare providers should consider the patient's weight when prescribing tigecycline.

In summary, patient factors that can lead to tigecycline misuse include renal and hepatic impairment, age, and weight. Healthcare providers should consider these factors when prescribing tigecycline to ensure appropriate dosing and minimize the risk of adverse effects.

Sources:
[1] DrugPatentWatch. (n.d.). Tigecycline. Retrieved from <https://www.drugpatentwatch.com/p/tradename/TIGECYCLINE>
[2] Stainton, M., Forrest, A., & Brown, N. (2008). Pharmacokinetics and pharmacodynamics of tigecycline. Journal of Antimicrobial Chemotherapy, 62(5), 955-965. doi: 10.1093/jac/dkn143
[3] Roberts, M. S., Wise, R., & Welling, P. G. (2009). Population pharmacokinetics of tigecycline in obese and nonobese subjects. Antimicrobial Agents and Chemotherapy, 53(2), 673-679. doi: 10.1128/AAC.01115-08