What is the half life of sildenafil?

See the DrugPatentWatch profile for sildenafil

What is sildenafil’s half-life?

Sildenafil has an elimination half-life of about 3 to 5 hours.

How long does that mean its effects may last?

Because sildenafil’s half-life is a few hours, the drug level in the body drops by about half every 3 to 5 hours after peak exposure. Clinical effects can still be noticeable longer than the half-life because effects depend on drug concentration in relevant tissues, not just the half-life.

Does the half-life change in certain people?

Yes. Sildenafil pharmacokinetics can shift with factors that affect drug metabolism and clearance, such as liver impairment and some drug interactions.