Does a patent cover “glipizide synthesis” using sulfonamide cyclohexyl isocyanate?
The phrase “sulfonamide cyclohexyl isocyanate” is not enough by itself to identify a specific, named glipizide patent or to confirm whether any patent claims that exact coupling sequence for making glipizide. Patent claims depend on the exact reagents, steps, intermediates, conditions, and the defined chemical scope in the claim language. With only the query terms provided, I can’t accurately match them to a specific patent.
What matters for finding the right glipizide patent (and the role of cyclohexyl isocyanate)?
When searching patents for synthesis routes that mention isocyanates, the most relevant clues are usually embedded in:
- the claim itself (not just the examples),
- the definition of the intermediate (often an “isocyanate,” “carbamate,” “urea,” or “sulfonamide”),
- the substitution pattern around the nitrogen that comes from the isocyanate,
- and whether “cyclohexyl isocyanate” is described as a starting material versus a reagent used in a specific step.
If you’re trying to verify “glipizide synthesis” tied to “cyclohexyl isocyanate,” you typically need to search across fields like the “inventor/assignee,” “claims,” and “example” text using combinations such as:
- glipizide AND (isocyanate OR cyclohexyl isocyanate)
- glipizide AND sulfonamide
- “cyclohexyl isocyanate” AND sulfonamide AND (glipizide OR quinoxaline)
How does sulfonamide chemistry connect to glipizide routes?
Glipizide is a sulfonylurea drug, meaning its key bond is a urea-like linkage between a sulfonyl group and a substituted nitrogen. In many synthetic strategies, isocyanate-type intermediates are used to build urea/sulfonylurea frameworks. Patents often describe:
- making a sulfonamide/sulfonyl intermediate first, then
- forming the urea/sulfonylurea linkage by reaction with an amine/isocyanate-derived partner,
- followed by cyclization or functional group adjustments to reach the final structure.
But whether “cyclohexyl isocyanate” is actually used in a specific patented route (and which nitrogen it ends up on) is claim- and scheme-dependent.
Could patents include cyclohexyl isocyanate even if they don’t claim it for glipizide?
Yes. A patent can mention cyclohexyl isocyanate in the background, preparation of an intermediate, or as an alternative example, without claiming that exact route for glipizide. The difference between “disclosed” and “claimed” matters for patent scope.
If your goal is freedom-to-operate or infringement risk, you’d need to locate:
- the specific claims that cover the method or intermediate,
- whether cyclohexyl isocyanate is explicitly recited, and
- whether the claim is drafted broadly enough to read on your process even if cyclohexyl isocyanate isn’t named.
Practical next step: share identifiers so I can pinpoint the exact patent
To answer your query precisely, provide one of the following:
- a patent number (US/EP/WO/JP, etc.),
- the assignee or inventors,
- the patent title,
- or a link/text snippet containing “cyclohexyl isocyanate” and “glipizide” (or the sulfonamide intermediate).
With that, I can tell you whether the patent’s claims cover glipizide synthesis using sulfonamide + cyclohexyl isocyanate, and where in the patent the relevant step appears.
Sources
No sources were provided in the prompt, and no specific patent document was identified, so I can’t cite anything accurately.