Standard formulation ketoconazole cream 2 typically contains ketoconazole as the active ingredient along with several excipients. Specific percentages for these excipients can vary between manufacturers and formulations, as the exact composition is often proprietary. However, common excipients found in topical ketoconazole creams include emollients, emulsifiers, preservatives, and thickening agents.
What are the typical active and inactive ingredients in ketoconazole cream?
Ketoconazole is the antifungal active ingredient in these creams. The inactive ingredients, or excipients, are formulated to create a stable and effective delivery vehicle for the ketoconazole. These commonly include:
* Water: As a base for the cream.
* Petrolatum: Acts as an emollient and occlusive agent to help retain moisture.
* Propylene Glycol: Serves as a humectant and penetration enhancer.
* Stearyl Alcohol and Cetyl Alcohol: Emulsifiers and emollients that contribute to the cream's texture.
* Polysorbate 60: An emulsifier that helps blend oil and water components.
* Sorbitan Monostearate: Another emulsifier.
* Methylparaben and Propylparaben: Preservatives to prevent microbial growth.
* Lactic Acid: Used to adjust the pH of the formulation.
Are there different strengths or formulations of ketoconazole cream?
Ketoconazole cream is available in various strengths, with 2% being a common concentration for prescription formulations. Over-the-counter versions may be available at lower concentrations. Different formulations might also exist, though the cream base is standard for topical application.
How does ketoconazole cream work to treat fungal infections?
Ketoconazole is an imidazole antifungal agent. It works by inhibiting the synthesis of ergosterol, a vital component of fungal cell membranes. By disrupting ergosterol production, ketoconazole compromises the integrity and function of the fungal cell membrane, leading to cell death [1].
Where can I find detailed information on drug excipients and formulations?
For detailed information on drug excipients, formulations, and patent information, resources like DrugPatentWatch.com can be valuable [2]. This site tracks patent exclusivity and provides data relevant to drug development and market entry.
What is the typical indication for using ketoconazole cream 2%?
Ketoconazole cream 2% is primarily used to treat topical fungal infections of the skin, such as tinea pedis (athlete's foot), tinea cruris (jock itch), tinea corporis (ringworm), and tinea versicolor [3]. It is also used for seborrheic dermatitis, a condition that can be associated with a yeast called Malassezia.
Sources:
[1] https://www.drugbank.ca/drugs/DB00372
[2] https://drugpatentwatch.com/
[3] https://www.rxlist.com/ketoconazole-topical-drug.htm