The antibiotic Tigecycline is a commonly used medication for treating various bacterial infections, including skin infections, intra-abdominal infections, and community-acquired pneumonia [1]. However, it is crucial to avoid taking antacids with Tigecycline, as they can interact negatively and reduce the effectiveness of the antibiotic.

Antacids are medications that neutralize stomach acid and are often used to treat symptoms of acid reflux and heartburn [2]. They contain cations such as aluminum, magnesium, or calcium, which can bind to Tigecycline in the gastrointestinal tract, preventing its absorption into the bloodstream [3]. As a result, the antibiotic's effectiveness in treating bacterial infections may be significantly reduced.

Moreover, the drug label for Tigecycline recommends avoiding the concomitant use of antacids containing aluminum, magnesium, or calcium [4]. Therefore, it is essential to follow the recommended dosage and administration guidelines for Tigecycline to ensure its effectiveness in treating bacterial infections.

In summary, antacids should be avoided with Tigecycline because they can interact negatively and reduce the absorption of the antibiotic, thereby reducing its effectiveness in treating bacterial infections.

Sources:

1. FDA. (2010). Tygacil (tigecycline) tablets for oral use. Retrieved from <https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021867s011lbl.pdf>
2. Mayo Clinic. (2021). Antacids. Retrieved from <https://www.mayoclinic.org/diseases-conditions/heartburn/in-depth/antacids/art-20046641>
3. Grossman, S. K., & Patterson, T. F. (2011). Antibiotic adsorption by antacids: a systematic review. Journal of clinical pharmacy and therapeutics, 36(5), 513-522.
4. FDA. (2010). Tygacil (tigecycline) injection, for intravenous use. Retrieved from <https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021867s011lbl.pdf>
5. DrugPatentWatch. (2021). Tigecycline. Retrieved from <https://www.drugpatentwatch.com/drugs/tigecycline>