How do you get Onpattro (patisiran) in the US?
Onpattro is a prescription medicine for hereditary transthyretin-mediated (hATTR) amyloidosis. To get it, you typically need:
- A diagnosis of hATTR amyloidosis confirmed by a specialist (often neurology or genetics/amyloidosis clinics).
- Prescriber approval and an active prescription for your specific indication and eligibility.
- Enrollment through the treatment pathway used by the manufacturer/health-system specialty channel (the exact steps can vary by clinic and insurance).
Because Onpattro is administered as an infusion, your prescribing team also coordinates infusion scheduling and monitoring.
What patients usually need before starting Onpattro
Clinicians generally evaluate eligibility based on the hATTR amyloidosis diagnosis and clinical criteria used for treatment decisions. They also plan supportive care for infusion tolerance, since Onpattro is given intravenously (not as pills).
What if you can’t afford Onpattro?
Most patients who need an expensive infusion medicine work through some mix of:
- Insurance coverage (commercial or government plans)
- Prior authorization from the insurer (commonly required for high-cost specialty drugs)
- Specialty pharmacy or infusion-center coordination
- Patient assistance or co-pay support programs run through the manufacturer (availability depends on plan type and eligibility)
If you tell me your country and whether you have insurance (and what type), I can point you to the most relevant route to start.
Who should you contact to start the process?
The fastest path usually starts with:
- Your neurologist or an amyloidosis specialist, if you have one
- If you do not, ask your primary care doctor for referral to an amyloidosis clinic or neurology specialty that manages hATTR patients
They can confirm eligibility, submit any prior authorization, and set up infusion logistics.
What does the insurance approval process typically involve?
For Onpattro, insurers commonly request documentation that you meet the labeled indication and may require:
- Prior authorization submission by the prescriber
- Diagnosis and clinical documentation (often including genetic testing results for hATTR)
- Treatment plan confirmation for infusion therapy
Are there alternatives if you can’t get Onpattro?
For hATTR amyloidosis, there are other disease-modifying options and supportive approaches depending on your subtype, severity, and eligibility. Your specialist can compare options based on your specific genetic variant and disease stage.
How long does it take to start after you’re approved?
Timing depends on the prior authorization turnaround and infusion scheduling at your center. After approval, the prescriber and infusion team typically finalize medication logistics and supportive premedication plans before the first dose.
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If you share (1) your country, (2) whether you already have a confirmed hATTR diagnosis, and (3) whether you have insurance, I can outline the most likely step-by-step path to get Onpattro.