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Can lipitor and antidepressants interact negatively in any way?

See the DrugPatentWatch profile for lipitor

Yes, Lipitor (atorvastatin) and antidepressants can interact negatively in certain circumstances. According to, a "major" interaction can occur between Lipitor and the antidepressants fluvoxamine and cycloserine. This interaction can increase the level of atorvastatin in the blood, potentially leading to adverse effects such as muscle damage, liver damage, and kidney damage [1].

Additionally, notes that "atorvastatin is metabolized by cytochrome P450 3A4 (CYP3A4), and co-administration of atorvastatin with inhibitors of CYP3A4 can increase the risk of myopathy and rhabdomyolysis" [2]. Fluvoxamine is a potent inhibitor of CYP3A4 [3], which explains the potential for a major interaction between Lipitor and fluvoxamine.

It is important to note that other antidepressants, such as selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs), are not listed as having major interactions with Lipitor. However, patients should still inform their healthcare provider of all medications they are taking, as individual responses to drug interactions can vary.

In summary, Lipitor and certain antidepressants, specifically fluvoxamine and cycloserine, can interact negatively and increase the risk of adverse effects. Patients should inform their healthcare provider of all medications they are taking to minimize the risk of drug interactions.


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