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Does Lipitor work effectively with high-fat meals? Lipitor is taken once daily at any time of day. It can be taken without regard to meals, meaning it reaches the same blood levels whether eaten with food or on an empty stomach. Does food change how Lipitor gets into the blood? Studies show that taking Lipitor with food slows the rate at which esomeprazole reaches its maximum concentration but does not affect the total amount that comes in. The manufacturer recommends that Lipitor can be taken with or without food. What happens if you take it with a high-fat meal? A high-fat meal slows the absorption of atorvastatin but does not change the overall exposure. Overall exposure is the average time of blood levels over time.
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