Daratumumab cost?

Daratumumab (Darzalex) pricing varies a lot by country, payer, formulation, and dose. In the U.S., the list price for daratumumab is high, and a full treatment cycle can cost tens to hundreds of thousands of dollars depending on weight and schedule. Here are some general points:

- Formulations:
- IV daratumumab (the original formulation)
- Subcutaneous daratumumab with hyaluronidase (Darzalex Faspro) – price per mg is similar, but the infusion is much shorter.
- Typical dosing (example, IV):
- 16 mg/kg per administration
- Weeks 1–8: weekly
- Weeks 9–24: every 2 weeks
- After that: every 4 weeks
- Each dose often requires multiple vials; the cost per dose can be substantial.
- Rough ballpark (US, just to give a sense):
- List price per 1,000 mg vial is commonly cited in the several-thousand-dollar range.
- A typical dose for an average adult (weight ~70–80 kg) is around 1,100–1,400 mg, which may require 3–4 vials per dose.
- So per-dose list price could be in the tens of thousands of dollars; a full initial cycle (often 8 weekly doses) can total in the high hundreds of thousands of dollars.
- Other regions: prices vary widely due to local pricing, rebates, and insurance coverage.
- How to get a clearer number:
- If you share your country and approximate weight, I can give a more concrete range.
- Check with the hospital/pharmacy and your insurer for exact out-of-pocket costs.
- Manufacturer assistance programs (e.g., Janssen Care Path) and payer sources can reduce patient cost or provide financial support.

If you’d like, tell me your country, weight, and whether you’re looking at IV or subcutaneous daratumumab, and I’ll tailor a rough estimate for you.