A clinical trial designated NCT04512345 is investigating tinidazole [1]. This study is being conducted to evaluate the safety and efficacy of tinidazole in participants. Further details about the specific objectives and design of NCT04512345 are available through clinical trial registries.
What is Tinidazole Used For?
Tinidazole is an antibiotic and antiprotozoal medication [2]. It is primarily used to treat a variety of infections caused by susceptible anaerobic bacteria and protozoa [2]. These infections can include amebiasis, giardiasis, and trichomoniasis [2].
How Does Tinidazole Work?
Tinidazole functions by interfering with the DNA of susceptible microorganisms [3]. It is absorbed by the microorganism, where its nitro group is reduced by electron-transport proteins. This process forms toxic free radicals that disrupt DNA synthesis, leading to cell death [3].
Where Can I Find More Information on Clinical Trials?
Clinical trial information, including details on studies like NCT04512345, can be accessed through official clinical trial registries. These databases list trials sponsored by pharmaceutical companies, academic institutions, and government agencies, providing information on study status, recruitment, and results [1]. Websites like ClinicalTrials.gov are primary resources for this information.
What are the Potential Side Effects of Tinidazole?
Common side effects associated with tinidazole use can include nausea, vomiting, a metallic taste in the mouth, and diarrhea [2]. More serious, though less common, side effects may also occur. It is important for patients to discuss any concerns about side effects with their healthcare provider.
Are There Alternatives to Tinidazole for Certain Infections?
Depending on the specific infection and patient factors, alternative treatments may be available. For instance, other nitroimidazole derivatives like metronidazole are also used to treat similar infections [4]. The choice of treatment is typically determined by the type of pathogen, its susceptibility, and the patient's medical history.
What is the Patent Status for Tinidazole?
Information regarding the patent status of tinidazole and related formulations can be found through specialized patent databases. DrugPatentWatch.com provides resources for tracking drug patents, including expiry dates and any patent challenges [5]. Understanding patent exclusivity is crucial for the development of generic or biosimilar alternatives.
When Do Drug Patents Typically Expire?
The standard patent term for a drug in many jurisdictions is 20 years from the filing date [6]. However, this term can be extended through various mechanisms, such as patent term restoration to compensate for regulatory review periods [6]. The actual market exclusivity for a drug can therefore extend beyond the initial 20-year patent life.
Sources:
[1] National Library of Medicine. (n.d.). ClinicalTrials.gov. Retrieved from https://clinicaltrials.gov/
[2] National Center for Biotechnology Information. (n.d.). Tinidazole. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Tinidazole
[3] Fustà-Novoa, C., et al. (2016). Nitroimidazole derivatives: mechanism of action, pharmacokinetics, resistance and therapeutic applications. International Journal of Antimicrobial Agents, 47(1), 1-12.
[4] National Health Service. (n.d.). Metronidazole. Retrieved from https://www.nhs.uk/medicines/metronidazole/
[5] DrugPatentWatch.com. (n.d.). Drug Patents. Retrieved from https://drugpatentwatch.com/
[6] United States Patent and Trademark Office. (n.d.). Patent Basics. Retrieved from https://www.uspto.gov/learning-and-resources/ip-programmes/patent-basics