Entresto generic substitute?

Entresto is a brand name for sacubitril/valsartan, an ARNI used for certain heart failure conditions.

- In the United States, as of now there isn’t a widely available generic sacubitril/valsartan yet (status can change with time).
- In some other countries, generic versions of sacubitril/valsartan are available from multiple manufacturers.

What you can do:
- Tell me your country or region, and I can look up the current generic status there.
- If cost is the concern, ask your prescriber about:
- Switching to a generic ARB or an ACE inhibitor (e.g., valsartan, losartan, lisinopril) if clinically appropriate. Note: these are not exact substitutes for Entresto and may require a change in monitoring and dosing.
- Other guideline-directed therapies for heart failure that can be used alongside standard meds (e.g., beta-blockers, MRAs like spironolactone or eplerenone, and SGLT2 inhibitors such as dapagliflozin or empagliflozin).
- Patient assistance programs, discount cards, or manufacturer savings programs that may apply to sacubitril/valsartan.
- Asking about generic substitution with your pharmacist (some plans or regions allow automatic substitution if a generic is available).

If you want, tell me your country and I’ll check the latest status and any cost-saving options available there.