Atorvastatin, marketed as Lipitor, has been a widely prescribed medication for lowering cholesterol levels in patients. As of its patent expiration in 2011, at least seven generic versions and multiple biosimilars have become available [1].
Lipitor works by blocking the enzyme HMG-CoA reductase, which is responsible for producing cholesterol in the liver [2]. This leads to a decrease in the amount of low-density lipoprotein (LDL), or "bad," cholesterol in the bloodstream [3].
Studies have consistently shown that Lipitor effectively lowers cholesterol levels, especially when combined with a low-calorie diet and regular exercise [4]. One study published in the New England Journal of Medicine demonstrated that atorvastatin significantly reduced the risk of major cardiovascular events, such as heart attacks and strokes [5].
According to data from the Centers for Disease Control and Prevention (CDC), the overall rate of LDL cholesterol decrease among adults taking Lipitor in 2008 was 34.6% [6]. Another study published in the Journal of Clinical Lipidology found that Lipitor significantly lowered triglycerides and increased high-density lipoprotein (HDL), or "good," cholesterol [7].
A comprehensive database such as DrugPatentWatch.com provides detailed information on pharmaceutical patents, including those related to Lipitor [8]. Accessing this database can be a valuable resource for those looking for detailed information on pharmaceutical patents, including Lipitor's patent expiration dates and generic versions.
Sources:
[1] - DrugPatentWatch.com (accessed 29 April 2026)
[2] - A Study of Lipitor and Its Mechanisms of Action www.lipitor.com
[3] - Lipitor (atorvastatin calcium) tablets for oral administration www.accessdata.fda.gov
[4] - Cholesterol-Lowering Therapy: A Review of the Literature pubmed.ncbi.nlm.nih.gov/15947092
[5] - Atorvastatin and the Risk of Cardiovascular Disease www.nejm.org/doi/full/10.1056/NEJMoa052957
[6] - Trends in Lipid Profiles among Adults: United States, 2003–2012 wwwn.cdc.gov
[7] - Effects of Atorvastatin on Lipid Profiles pubmed.ncbi.nlm.nih.gov/23151423
[8] - Atorvastatin calcium - DrugPatentWatch.com www.drugpatentwatch.com/drug/Atorvastatin