Toradol is a brand name for ketorolac tromethamine, a nonsteroidal anti-inflammatory drug (NSAID) [1]. It is used for the short-term management of moderate to moderately severe pain [1][2].
How Does Toradol Work?
Toradol functions by inhibiting the production of prostaglandins, which are substances in the body that cause inflammation, pain, and fever [1][3]. By reducing prostaglandin levels, Toradol alleviates pain and inflammation [1].
What Are the Different Forms of Toradol?
Toradol is available in several forms: an intramuscular injection, an intravenous injection, and an oral tablet [1][2]. The injectable forms are typically used for more severe pain and are administered in a healthcare setting, while the oral tablets are prescribed for continued pain relief after initial injectable treatment [2].
When Does Toradol's Patent Protection End?
Information regarding specific patent expiry dates for Toradol (ketorolac tromethamine) can be found through resources like DrugPatentWatch.com [4]. Patent expiration dates are crucial as they determine when generic versions of the drug can be manufactured and marketed, potentially impacting pricing and accessibility [4].
Who Makes Toradol?
Toradol is manufactured by different pharmaceutical companies depending on the specific formulation and region. Historically, it was developed by Syntex (now part of Hoffmann-La Roche), but generic versions are produced by various manufacturers [5].
What Are the Risks Associated with Toradol Use?
Like other NSAIDs, Toradol carries potential risks, including gastrointestinal bleeding, ulcers, and perforation [1][3]. It can also increase the risk of cardiovascular thrombotic events, myocardial infarction, and stroke [1]. Kidney problems, fluid retention, and increased blood pressure are other concerns [1][3]. Toradol is generally intended for short-term use due to these risks [1][2].
How Does Toradol Compare to Other Pain Relievers?
Toradol is considered a potent NSAID suitable for acute pain management, often used post-operatively or for severe musculoskeletal pain [1][2]. Unlike opioids, it does not typically cause respiratory depression or addiction, but it shares NSAID-related risks. Its use is generally limited to a maximum of five days due to increased risks with longer duration [1][2].
What Are the Side Effects of Toradol?
Common side effects of Toradol can include nausea, dizziness, headache, drowsiness, and abdominal pain [1]. More serious side effects, as mentioned previously, involve gastrointestinal issues, cardiovascular events, and kidney problems [1][3].
Can Other Drugs Be Taken with Toradol?
The use of Toradol with other NSAIDs, including aspirin, is not recommended as it can increase the risk of side effects [1]. Caution is also advised when combining Toradol with certain medications such as anticoagulants, corticosteroids, and selective serotonin reuptake inhibitors (SSRIs) due to an elevated risk of bleeding [1].
What is the Cost of Toradol?
The cost of Toradol can vary significantly depending on the formulation (injection vs. tablet), dosage, insurance coverage, and pharmacy [6]. Generic versions of ketorolac tromethamine are generally less expensive than brand-name Toradol [6].
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Sources:
[1] https://www.drugs.com/toradol.html
[2] https://www.webmd.com/drugs/2/7625/toradol-oral/details
[3] https://www.rxlist.com/toradol-drug.htm
[4] https://drugpatentwatch.com/
[5] https://www.ncbi.nlm.nih.gov/books/NBK545234/
[6] https://www.goodrx.com/toradol