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Does high fiber intake boost Lipitor effectiveness? High fiber diets can reduce how much atorvastatin (Lipitor) gets into the blood. Soluble fiber binds cholesterol and bile acids in the gut, which may also bind some of the drug and lower its absorption. Studies show patients on high-fiber diets sometimes need higher doses to reach the same statin effect. Does timing of fiber and Lipitor matter? Taking Lipitor at bedtime and fiber supplements or high-fiber meals at least two hours apart minimizes any interaction. Most doctors recommend this separation because atorvastatin is absorbed quickly in the small intestine, while fiber stays in the gut for longer. What happens if you keep both ho
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