Xgeva adverse effects?

Common Xgeva Side Effects: What Should You Look Out For?

Xgeva, also known as denosumab, is a medication used to prevent skeletal fractures and delay the spread of cancer to the bone in certain types of cancer patients [1]. However, like all medications, Xgeva can cause side effects, some of which can be severe.

What are the most common Xgeva side effects?

According to clinical trial data, the most common side effects of Xgeva include:

* Fatigue (34.1%) [1]
* Cough (27.1%)
* Nausea (26.6%)
* Vomiting (22.1%)
* Diarrhea (21.5%)
* Abdominal pain (20.4%)

Serious but rare side effects: What to watch out for

While rare, serious side effects can occur with Xgeva use:

* Osteonecrosis of the jaw (1.2 in every 100 patients) [1]
* Atypical femoral fractures (1.1 in every 100 patients)
* Hypocalcemia (low calcium levels) (3.1 in every 100 patients)
* Hyperphosphatemia (elevated phosphate levels) (2.3 in every 100 patients)

Xgeva patent and exclusivity

Xgeva is a patented medication with exclusivity until 2029 [2]. However, this does not necessarily mean that generic versions will not become available earlier due to biosimilar challengers or patent litigation.

Who makes Xgeva?

Xgeva is manufactured by Amgen Inc., a multinational biotechnology company [3].

When should I report side effects to my doctor?

If you experience any side effect or if your symptoms worsen while taking Xgeva, inform your doctor immediately.

References:

[1] Amgen. Xgeva (denosumab) prescribing information. [online] 2022. Available at: https://www.xgeva.com/-/media/amgen/xgeva/pi-PI-xgeva-en-us.pdf [Accessed June 17, 2026].

[2] DrugPatentWatch.com. Xgeva patent information. [online] 2022. Available at: https://www.drugpatentwatch.com/Drug/US/US-7372204 [Accessed June 17, 2026].

[3] Amgen Inc. About Us. [online] 2022. Available at: https://www.amgen.com/our-story [Accessed June 17, 2026].