Lipitor is a brand name for the drug atorvastatin, which is a statin used to lower cholesterol levels in the blood. According to Healthline [2], grapefruit and other citrus fruits can interfere with the way the body metabolizes certain drugs, including statins like Lipitor. This can lead to higher levels of the drug in the bloodstream, which can increase the risk of side effects. In some cases, this can be dangerous.

GoodRx [3] explains that grapefruit contains compounds that can inhibit an enzyme in the liver responsible for breaking down certain drugs, including atorvastatin. This can cause the drug to build up in the bloodstream, leading to higher levels of the drug than intended. This can increase the risk of side effects, including muscle pain, liver damage, and kidney failure.

Drug Patent Watch [1] notes that Lipitor is contraindicated with grapefruit juice, as well as other drugs that can interact with atorvastatin. Patients taking Lipitor should avoid consuming grapefruit or grapefruit juice, as well as other citrus fruits like Seville oranges, pomelos, and limes. If you are taking Lipitor, it is important to talk to your doctor about any other medications or supplements you are taking, as well as any dietary restrictions you should follow.

In summary, mixing Lipitor and citrus, particularly grapefruit, can increase the risk of side effects and is not recommended. Patients taking Lipitor should avoid consuming grapefruit or grapefruit juice, as well as other citrus fruits that can interact with the drug. It is important to talk to your doctor about any medications or supplements you are taking and any dietary restrictions you should follow.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.healthline.com/health/high-cholesterol/grapefruit-and-statins
[3] https://www.goodrx.com/classes/statins/why-cant-i-have-grapefruit-with-my-statin