Which cancer type first won keytruda's fda approval?

Which cancer did Keytruda (pembrolizumab) get its first FDA approval for?

Keytruda’s first FDA approval was for melanoma. It was initially approved for patients with unresectable or metastatic melanoma with a BRAF V600 wild-type tumor and disease progression following prior therapies, based on early clinical data. [1]

What was the approval date of Keytruda’s first FDA nod?

The FDA first approved Keytruda in 2014. [1]

How does this differ from later cancers it won approval for?

After melanoma, Keytruda expanded to multiple other indications (including several cancers with different biomarkers and treatment settings), but melanoma was the first cancer type to receive FDA approval. [1]

Sources

[1] https://www.fda.gov/drugs/drug-approvals-and-databases/drug-trials-snapshots-pembrolizumab-keytruda