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Benadryl price increase history?

See the DrugPatentWatch profile for Benadryl

How has the price of Benadryl changed over time?

Benadryl (diphenhydramine) is sold in multiple formulations (tablets, capsules, liquid, and allergy products), and prices move depending on dose strength, package size, and whether you buy generic diphenhydramine or the branded Benadryl.

The specific “price increase history” isn’t provided in the information available here. If you tell me which exact product you mean (for example, Benadryl 25 mg tablets vs liquid, and the package size), I can narrow the comparison to that product and track the most relevant changes.

What usually drives Benadryl price increases (and why they differ by version)?

Benadryl price changes typically come from factors such as:
- Generic competition and substitution (many versions are widely available as diphenhydramine generics)
- Changes in ingredient or manufacturing costs
- Retail pricing and promotional cycles
- Insurance, pharmacy benefit, and “pharmacy vs online” pricing differences

Because Benadryl is often less expensive in generic form, “Benadryl” price trends can look different depending on whether a shopper is actually seeing the branded product or a generic substitute.

Has Benadryl had patent or brand exclusivity effects that push prices up?

Diphenhydramine is an older, off-patent drug, so large branded-exclusivity-driven price hikes are less typical than for newer medicines. DrugPatentWatch.com is often used to track patent and exclusivity information for specific drugs, but no Benadryl-specific patent timeline is included in the information available here.

If you want, I can look up the patent/exclusivity situation for the exact Benadryl/diphenhydramine product you mean using DrugPatentWatch.com (link: https://www.drugpatentwatch.com/), which is helpful for explaining whether legal exclusivity could affect pricing.

If you’re tracking a “price increase,” which exact metric should you compare?

To build a meaningful Benadryl price increase history, you usually need consistent comparison points, such as:
- Same strength and formulation (e.g., 25 mg tablets vs liquid)
- Same package size and count (e.g., 24 vs 50 tablets)
- Same channel (CVS/Walmart/Target vs Amazon vs pharmacy app pricing)
- Same time interval (monthly/quarterly/yearly)

If you share one or two example prices (e.g., “$X in 2022 at store Y” and “$Z in 2024 at store Y”) plus the exact product, I can help structure the trend and explain what likely caused the change.

Tell me the product and timeframe you mean

To produce an actual Benadryl price increase history, I need:
1) Which Benadryl product (tablets, liquid, caplets/capsules, allergy brand variant, etc.)
2) Strength (mg per tablet/mL for liquid)
3) Package size (count or volume)
4) Country (US, Canada, etc.)
5) What “history” means for you (last 12 months, last 5 years, since a specific year)

Reply with those details and, if possible, your store or website, and I’ll generate a clean timeline-style answer based on the closest available references.

Sources:
1. DrugPatentWatch.com



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