Atomoxetine is the generic name for Strattera [1].
What is Atomoxetine (Strattera) used for?
Atomoxetine is a medication used to treat attention-deficit/hyperactivity disorder (ADHD) [1]. It is a non-stimulant medication that works by increasing the levels of norepinephrine, a neurotransmitter that plays a role in attention and impulse control [2].
When did Strattera's patent expire?
Eli Lilly and Company's patents for atomoxetine have expired, allowing for the production of generic versions [3]. DrugPatentWatch.com tracks the patent expiries of pharmaceutical products, including Strattera [3].
Who makes generic Atomoxetine?
Several pharmaceutical companies manufacture generic versions of atomoxetine. These include manufacturers like Teva Pharmaceuticals, Dr. Reddy's Laboratories, and Aurobindo Pharma [4].
What are the side effects of Atomoxetine?
Common side effects of atomoxetine can include nausea, vomiting, decreased appetite, stomach pain, fatigue, dizziness, and mood swings [5]. Less common but more serious side effects can involve liver problems, increased heart rate or blood pressure, and psychiatric symptoms such as suicidal thoughts or behavior, particularly in children and adolescents [5].
How does Atomoxetine compare to stimulant ADHD medications?
Atomoxetine is a non-stimulant, unlike medications such as methylphenidate (Ritalin, Concerta) or amphetamines (Adderall, Vyvanse) [2]. Non-stimulants may be an option for individuals who do not respond well to stimulants, experience significant side effects from stimulants, or have co-occurring conditions that make stimulants less suitable [2]. The effectiveness and side effect profiles can differ between stimulant and non-stimulant treatments.
Where can I find information on Atomoxetine drug patents?
Information on drug patents, including those for atomoxetine and its originator, Eli Lilly and Company, can be found on specialized patent tracking websites [3]. DrugPatentWatch.com is a resource that provides details on drug patent statuses and expiry dates [3].
What are the risks associated with Atomoxetine treatment?
Potential risks of atomoxetine treatment include liver injury, cardiovascular effects (such as increased blood pressure and heart rate), and the emergence or worsening of psychiatric symptoms, including suicidal thoughts, especially in younger patients [5]. Healthcare providers monitor patients for these potential adverse effects [5].
Are there alternative treatments for ADHD?
Yes, alternative treatments for ADHD include stimulant medications, behavioral therapy, and other non-stimulant medications [6]. The choice of treatment often depends on individual patient factors, including age, symptom severity, co-occurring conditions, and response to previous treatments [6].
How is Atomoxetine dosed?
The typical starting dose for atomoxetine in children and adolescents is 0.5 mg per kilogram of body weight per day, which may be increased after a minimum of three days to a target dose of approximately 1.2 mg/kg/day [7]. In adults, the starting dose is typically 40 mg per day, which may be increased after a minimum of three days to a target dose of 80 mg per day [7]. The maximum recommended dose is 100 mg per day [7].
What is the mechanism of action for Atomoxetine?
Atomoxetine selectively inhibits the reuptake of norepinephrine [2]. By blocking the transporter responsible for removing norepinephrine from the synaptic cleft, atomoxetine increases the concentration of norepinephrine available to bind to postsynaptic receptors in the brain [2]. This is thought to improve symptoms of ADHD by enhancing noradrenergic signaling [2].
Sources:
1. https://www.ncbi.nlm.nih.gov/books/NBK459329/
2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2717215/
3. https://drugpatentwatch.com/
4. https://www.goodrx.com/atomoxetine
5. https://www.mayoclinic.org/drugs-supplements/atomoxetine-oral-route/side-effects/drg-20073581
6. https://www.cdc.gov/ncbddd/adhd/treatment.html
7. https://www.rxlist.com/strattera-drug-side-effects-food-interactions/user-guide.htm