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Price of promethazine with codeine?

See the DrugPatentWatch profile for promethazine

Promethazine + Codeine – Rough Price Ranges (U.S. example)

Form Typical Cost Range (Retail, no insurance)
30‑tablet bottle (5 mg codeine + 25 mg promethazine) $30 – $80
90‑tablet bottle $70 – $180

What influences the price?

  1. Brand vs. generic – The brand name (e.g., Codyne, Promexine‑Codeine) can be 2–4× more expensive than the generic combination.
  2. Insurance – Most health plans cover a portion or the full cost, often reducing the out‑of‑pocket amount to $10–$30 for a 30‑tablet pack.
  3. Pharmacy – Prices can differ by pharmacy chain, independent drugstore, or mail‑order services.
  4. Location – State or regional variations in pharmacy pricing, plus differences in pharmacy benefit manager (PBM) contracts, can shift the final cost.

Ways to reduce cost

  • Generic prescription: Ask your prescriber if the generic version is acceptable.
  • Prescription discount cards: Many pharmacy benefit programs and discount card sites (e.g., GoodRx, Blink) provide coupons that can cut the price by 20–60 %.
  • Mail‑order pharmacy: Some insurance plans offer a mail‑order option with a lower co‑pay.
  • Check multiple pharmacies: Prices for the same prescription can vary by as much as $20–$30 at different locations.

Important reminder

  • Always consult a healthcare professional before taking promethazine or codeine. Both drugs are opioids (codeine) and antihistamines (promethazine), and they have potential for dependence, sedation, and other side‑effects.
  • Insurance and formulary status can change; the actual out‑of‑pocket cost for you may differ from the ranges above.

If you’re looking for the precise cost at your local pharmacy, it’s best to call ahead or use a pharmacy‑price‑comparison tool.



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