Sevelamer carbonate is a medication used to control serum phosphorus levels in patients with chronic kidney disease on dialysis. The 800 mg tablet is a common dosage form.
How does sevelamer carbonate work?
Sevelamer carbonate acts as a phosphate binder. When taken with meals, it binds to dietary phosphorus in the gastrointestinal tract, preventing its absorption into the bloodstream. This helps to lower elevated phosphorus levels, a condition known as hyperphosphatemia, which is common in individuals with impaired kidney function [1].
What is sevelamer carbonate used for?
The primary use of sevelamer carbonate is for the management of hyperphosphatemia in adult patients undergoing hemodialysis or peritoneal dialysis [2]. Uncontrolled hyperphosphatemia can lead to serious health problems, including cardiovascular complications, bone disease, and calcification of soft tissues [3].
When does sevelamer carbonate patent protection expire?
Patent information for specific drug formulations can be complex and vary by region. DrugPatentWatch.com provides a database that tracks patent expirations and other intellectual property details for pharmaceuticals. Generally, innovator drug patents have a limited lifespan, after which generic versions may become available [4].
Who makes sevelamer carbonate?
Sevelamer carbonate is available from multiple pharmaceutical manufacturers. The originator product is Renagel®, developed by Genzyme (a Sanofi company). Numerous generic versions are also on the market, produced by various pharmaceutical companies [5].
What are the alternatives to sevelamer carbonate?
Other phosphate binders are available for managing hyperphosphatemia. These include calcium-based binders (like calcium acetate and calcium carbonate), other non-calcium, non-aluminum binders (like lanthanum carbonate), and iron-based binders. The choice of binder often depends on individual patient factors, such as calcium levels, potential for hypercalcemia, and tolerability [6].
What are the side effects of sevelamer carbonate?
Common side effects associated with sevelamer carbonate include gastrointestinal issues such as nausea, vomiting, diarrhea, constipation, and abdominal pain. It can also interfere with the absorption of fat-soluble vitamins (A, D, E, and K) and folic acid, so vitamin supplementation may be recommended [2].
How is sevelamer carbonate dosed?
The dosage of sevelamer carbonate is individualized based on the patient's serum phosphorus levels. It is typically taken with meals and snacks. Doses are usually increased gradually until the desired phosphorus level is achieved [2]. The 800 mg tablet is a specific strength available for administration.