Lipitor, also known as atorvastatin, is a medication used to lower cholesterol levels in the blood [1]. Antidepressants, on the other hand, are a class of drugs used to treat various mental health conditions, such as depression, anxiety, and obsessive-compulsive disorder [2].

According to a study published in the Journal of Affective Disorders, the combination of atorvastatin and antidepressants was found to be safe and effective in treating patients with depression and high cholesterol levels [3]. The study found that the combination therapy did not result in any significant adverse effects and was well-tolerated by the patients. Additionally, the study found that the combination therapy was more effective in treating depression than atorvastatin alone.

Another study published in the journal, Drug and Therapeutics Bulletin, also supports the safety of combining atorvastatin and antidepressants [4]. The study concluded that there is no evidence to suggest that combining these medications is unsafe or increases the risk of adverse effects.

However, it is important to note that every patient is unique and may react differently to medications. Therefore, it is important to consult with a healthcare provider before starting any new medication or combination therapy.

In conclusion, based on the provided sources, the combination of Lipitor and antidepressants appears to be safe and effective in treating patients with depression and high cholesterol levels. However, it is important to consult with a healthcare provider before starting any new medication or combination therapy.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827898/
[3] https://pubmed.ncbi.nlm.nih.gov/28303466/
[4] https://dtb.bmj.com/content/49/7/78